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No certain dose adjustment proposed when tofacitinib coadministered with strong CYP2C19 inhibitors; lower tofacitinib dose if coadministered with both of those moderate CYP3A4 and strong CYP2C19 inhibitors .modafinil will minimize the extent or influence of fruquintinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Altern
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